{ "_id": "6ad11809a6a61792ed76b143", "Package": "riskclustr", "Type": "Package", "Title": "Functions to Study Etiologic Heterogeneity", "Version": "0.4.1", "Authors@R": "person(given = \"Emily C.\", family = \"Zabor\", email = \"zabore2@ccf.org\", role = c(\"aut\", \"cre\"))", "Description": "A collection of functions related to the study of\netiologic heterogeneity both across disease subtypes and across\nindividual disease markers. The included functions allow one to\nquantify the extent of etiologic heterogeneity in the context\nof a case-control study, and provide p-values to test for\netiologic heterogeneity across individual risk factors. Begg\nCB, Zabor EC, Bernstein JL, Bernstein L, Press MF, Seshan VE\n(2013) .", "License": "GPL-2", "URL": "https://www.emilyzabor.com/riskclustr/,\nhttps://github.com/zabore/riskclustr", "BugReports": "https://github.com/zabore/riskclustr/issues", "Encoding": "UTF-8", "Language": "en-US", "LazyData": "true", "Roxygen": "list(markdown = TRUE)", "RoxygenNote": "7.2.3", "VignetteBuilder": "knitr", "Config/pak/sysreqs": "libicu-dev", "Repository": "https://zabore.r-universe.dev", "Date/Publication": "2026-10-15 17:31:48 UTC", "RemoteUrl": "https://github.com/zabore/riskclustr", "RemoteRef": "HEAD", "RemoteSha": "fa0fdb088ed5a240f9ceccf2ab02a39fe096bf8c", "NeedsCompilation": "no", "Packaged": { "Date": "2026-10-15 18:10:38 UTC", "User": "root" }, "Author": "Emily C. Zabor [aut, cre]", "Maintainer": "Emily C. Zabor ", "_user": "zabore", "_type": "src", "_file": "riskclustr_0.4.1.tar.gz", "_fileid": "https://r2.ropensci.org/a00f85007ec4f6ff7864b0d49f8d90112b4dbdc1e41c8d18ea8050fb84797506", "_filesize": 461649, "_sha256": "a00f85007ec4f6ff7864b0d49f8d90112b4dbdc1e41c8d18ea8050fb84797506", "_expires": "2027-01-23T18:14:31.000Z", "_created": "2026-10-15T18:10:38.000Z", "_published": "2026-10-15T18:14:33.039Z", "_buildurl": "https://github.com/r-universe/zabore/actions/runs/38782863358", "_status": "success", "_host": "GitHub-Actions", "_jobs": [ { "job": 116589446494, "time": 139, "config": "linux-devel-x86_64", "r": "4.7.0", "check": "OK", "artifact": "11997155372" }, { "job": 116589446415, "time": 183, "config": "linux-release-x86_64", "r": "4.6.1", "check": "OK", "artifact": "11997425293" }, { "job": 116589446676, "time": 166, "config": "macos-oldrel-arm64", "r": "4.5.3", "check": "OK", "artifact": "11995774801" }, { "job": 116589446419, "time": 166, "config": "macos-release-arm64", "r": "4.6.1", "check": "OK", "artifact": "11997420127" }, { "job": 116587407267, "time": 254, "config": "source", "r": "4.6.1", "check": "OK", "artifact": "11996787482" }, { "job": 116589446552, "time": 111, "config": "wasm-release", "r": "4.6.0", "check": "OK", "artifact": "11997250305" }, { "job": 116589446574, "time": 98, "config": "windows-devel-x86_64", "r": "4.7.0", "check": "OK", "artifact": "11997245253" }, { "job": 116589446607, "time": 103, "config": "windows-oldrel-x86_64", "r": "4.5.3", "check": "OK", "artifact": "11997005472" }, { "job": 116589446857, "time": 89, "config": "windows-release-x86_64", "r": "4.6.1", "check": "OK", "artifact": "11996767840" } ], "_upstream": "https://github.com/zabore/riskclustr", "_commit": { "id": "fa0fdb088ed5a240f9ceccf2ab02a39fe096bf8c", "author": "Emily C. Zabor ", "committer": "Emily C. Zabor ", "message": "update README\n", "time": 1792085508 }, "_maintainer": { "name": "Emily C. Zabor", "email": "zabore2@ccf.org", "login": "zabore-ccf", "description": "Associate Staff Cancer Biostatistician at Cleveland Clinic in the Depratment of Quantitative Health Sciences & Taussig Cancer Center", "uuid": 294570735 }, "_distro": "resolute", "_registered": true, "_dependencies": [ { "package": "R", "version": ">= 4.0", "role": "Depends" }, { "package": "mlogit", "role": "Imports" }, { "package": "stringr", "role": "Imports" }, { "package": "Matrix", "role": "Imports" }, { "package": "testthat", "role": "Suggests" }, { "package": "covr", "role": "Suggests" }, { "package": "rmarkdown", "role": "Suggests" }, { "package": "dplyr", "role": "Suggests" }, { "package": "knitr", "role": "Suggests" }, { "package": "usethis", "role": "Suggests" }, { "package": "spelling", "role": "Suggests" } ], "_owner": "zabore", "_selfowned": true, "_usedby": 0, "_updates": [ { "week": "2026-42", "n": 1 } ], "_tags": [], "_stars": 1, "_contributors": [ { "user": "zabore", "count": 123, "uuid": 24287346 } ], "_userbio": { "uuid": 24287346, "type": "user", "name": "Emily C. Zabor", "followers": 196 }, "_downloads": { "count": 298, "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/riskclustr" }, "_devurl": "https://github.com/zabore/riskclustr", "_pkgdown": "https://www.emilyzabor.com/riskclustr/", "_searchresults": 35, "_rbuild": "4.6.1", "_assets": [ "extra/citation.cff", "extra/citation.html", "extra/citation.json", "extra/citation.txt", "extra/contents.json", "extra/manual.pdf", "extra/NEWS.html", "extra/NEWS.txt", "extra/readme.html", "extra/readme.md", "extra/riskclustr.html" ], "_homeurl": "https://github.com/zabore/riskclustr", "_realowner": "zabore", "_cranurl": true, "_releases": [ { "version": "0.1.0", "date": "2019-01-17" }, { "version": "0.2", "date": "2019-09-07" }, { "version": "0.3", "date": "2020-05-26" }, { "version": "0.4.0", "date": "2022-03-23" }, { "version": "0.4.1", "date": "2024-01-18" } ], "_exports": [ "d", "dstar", "eh_test_marker", "eh_test_subtype", "optimal_kmeans_d", "posthoc_factor_test" ], "_datasets": [ { "name": "subtype_data", "title": "Simulated subtype data", "object": "subtype_data", "class": [ "data.frame" ], "fields": [ "case", "subtype", "subtype_name", "marker1", "marker2", "x1", "x2", "x3", "y1", "y2", "y3", "y4", "y5", "y6", "y7", "y8", "y9", "y10", "y11", "y12", "y13", "y14", "y15", "y16", "y17", "y18", "y19", "y20", "y21", "y22", "y23", "y24", "y25", "y26", "y27", "y28", "y29", "y30" ], "rows": 2000, "table": true, "tojson": true } ], "_help": [ { "page": "d", "title": "Estimate the incremental explained risk variation in a case-control study", "topics": [ "d" ] }, { "page": "dstar", "title": "Estimate the incremental explained risk variation in a case-only study", "topics": [ "dstar" ] }, { "page": "eh_test_marker", "title": "Test for etiologic heterogeneity of risk factors according to individual disease markers in a case-control study", "topics": [ "eh_test_marker" ] }, { "page": "eh_test_subtype", "title": "Test for etiologic heterogeneity of risk factors according to disease subtypes in a case-control study", "topics": [ "eh_test_subtype" ] }, { "page": "optimal_kmeans_d", "title": "Obtain optimal D solution based on k-means clustering of disease marker data in a case-control study", "topics": [ "optimal_kmeans_d" ] }, { "page": "posthoc_factor_test", "title": "Post-hoc test to obtain overall p-value for a factor variable used in a 'eh_test_subtype' fit.", "topics": [ "posthoc_factor_test" ] }, { "page": "subtype_data", "title": "Simulated subtype data", "topics": [ "subtype_data" ] } ], "_readme": "https://github.com/zabore/riskclustr/raw/HEAD/README.md", "_rundeps": [ "cli", "CompQuadForm", "dfidx", "Formula", "generics", "glue", "lattice", "lifecycle", "lmtest", "magrittr", "Matrix", "micsr", "mlogit", "numDeriv", "rbibutils", "Rcpp", "Rdpack", "rlang", "sandwich", "stringi", "stringr", "survival", "vctrs", "zoo" ], "_vignettes": [ { "source": "contribute.Rmd", "filename": "contribute.html", "title": "Contribute to riskclustr", "author": "Emily C. Zabor", "engine": "knitr::rmarkdown", "headings": [ "Report an issue", "Suggest a change", "Contribute new functionality" ], "created": "2019-03-18 14:40:52", "modified": "2022-03-22 16:48:29", "commits": 2 }, { "source": "calculate_d.Rmd", "filename": "calculate_d.html", "title": "Tutorial: Estimate the extent of etiologic heterogeneity", "author": "Emily C. Zabor", "engine": "knitr::rmarkdown", "headings": [ "Introduction", "Case-control methods", "Case-only methods" ], "created": "2018-11-13 21:30:37", "modified": "2024-01-18 19:45:30", "commits": 10 }, { "source": "optimal_d.Rmd", "filename": "optimal_d.html", "title": "Tutorial: Identify the optimal D subtype solution", "author": "Emily C. Zabor", "engine": "knitr::rmarkdown", "headings": [ "Introduction", "Example" ], "created": "2018-11-24 21:15:13", "modified": "2018-12-21 20:14:49", "commits": 5 }, { "source": "factor_pvalue.Rmd", "filename": "factor_pvalue.html", "title": "Tutorial: Obtain an overall p-value for a factor variable", "author": "Emily C. Zabor", "engine": "knitr::rmarkdown", "headings": [ "Context", "Example" ], "created": "2019-08-21 15:52:25", "modified": "2019-08-21 15:52:25", "commits": 1 }, { "source": "eh_test.Rmd", "filename": "eh_test.html", "title": "Tutorial: Test for etiologic heterogeneity in a case-control study", "author": "Emily C. Zabor", "engine": "knitr::rmarkdown", "headings": [ "Introduction", "Pre-specified subtypes", "Subtypes formed by cross-classification of disease markers" ], "created": "2018-11-14 22:24:45", "modified": "2024-01-18 19:45:30", "commits": 9 } ], "_score": 4.942008053022313, "_indexed": true, "_nocasepkg": "riskclustr", "_universes": [ "zabore", "zabore-ccf" ], "_binaries": [ { "r": "4.7.0", "os": "linux", "version": "0.4.1", "date": "2026-10-15T18:12:59.000Z", "distro": "resolute", "commit": "fa0fdb088ed5a240f9ceccf2ab02a39fe096bf8c", "fileid": "https://r2.ropensci.org/4fdd7e226e6b5e6854498415b62305e1341edd3223177dbbefbc9a3f85704517", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/zabore/actions/runs/38782863358" }, { "r": "4.6.1", "os": "linux", "version": "0.4.1", "date": "2026-10-15T18:13:43.000Z", "distro": "resolute", "commit": "fa0fdb088ed5a240f9ceccf2ab02a39fe096bf8c", "fileid": "https://r2.ropensci.org/e8a121b46d355c1b800b4879b8e3e425943bfd45cd9b4fb2c74f10303b4ad8de", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/zabore/actions/runs/38782863358" }, { "r": "4.5.3", "os": "mac", "version": "0.4.1", "date": "2026-10-15T18:13:12.000Z", "commit": "fa0fdb088ed5a240f9ceccf2ab02a39fe096bf8c", "fileid": "https://r2.ropensci.org/746dc61c656d20c4dd1cad270e7643f3eef919ac9966bb77ad78e3de973e1f60", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/zabore/actions/runs/38782863358" }, { "r": "4.6.1", "os": "mac", "version": "0.4.1", "date": "2026-10-15T18:13:06.000Z", "commit": "fa0fdb088ed5a240f9ceccf2ab02a39fe096bf8c", "fileid": "https://r2.ropensci.org/094f36961dec8ce74a5fe437047a8d9b629d2bc04d14e876db4077030c26371a", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/zabore/actions/runs/38782863358" }, { "r": "4.6.0", "os": "wasm", "version": "0.4.1", "date": "2026-10-15T18:12:50.000Z", "commit": "fa0fdb088ed5a240f9ceccf2ab02a39fe096bf8c", "fileid": "https://r2.ropensci.org/95329fe7e1b936ce76fcde413475527bfd5da048be9d5c65380a33fda35369ed", "status": "success", "buildurl": "https://github.com/r-universe/zabore/actions/runs/38782863358" }, { "r": "4.7.0", "os": "win", "version": "0.4.1", "date": "2026-10-15T18:12:13.000Z", "commit": "fa0fdb088ed5a240f9ceccf2ab02a39fe096bf8c", "fileid": "https://r2.ropensci.org/4c7afbf30541375a0b0f34c12ab8b249bdd95411306a9bc65d4b659f0b1362b9", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/zabore/actions/runs/38782863358" }, { "r": "4.5.3", "os": "win", "version": "0.4.1", "date": "2026-10-15T18:12:12.000Z", "commit": "fa0fdb088ed5a240f9ceccf2ab02a39fe096bf8c", "fileid": "https://r2.ropensci.org/cefc63b615abe25eb6191361ac43fa63d48908dacf67f32a95034864ac788edf", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/zabore/actions/runs/38782863358" }, { "r": "4.6.1", "os": "win", "version": "0.4.1", "date": "2026-10-15T18:12:05.000Z", "commit": "fa0fdb088ed5a240f9ceccf2ab02a39fe096bf8c", "fileid": "https://r2.ropensci.org/2bd2be9b9e127439866e5571001d5ca7ae8ea1e36c80a6bd1dea62c50a674b3a", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/zabore/actions/runs/38782863358" } ] }